|
Polycystic Ovary Syndrome
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis suggested that LEPR rs1137101, PPARG rs1801282, and rs3856806 polymorphisms were all significantly associated with individual susceptibility to PCOS in certain populations.
|
31412346 |
2019 |
|
Malignant neoplasm of stomach
|
|
0.080 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
Stomach Carcinoma
|
|
0.080 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
Hypertensive disease
|
|
0.070 |
GeneticVariation
|
BEFREE |
Association between peroxisome proliferator-activated receptor γ-2 gene Pro12Ala polymorphisms and risk of hypertension: an updated meta-analysis.
|
30777927 |
2019 |
|
Impaired cognition
|
|
0.060 |
GeneticVariation
|
BEFREE |
Our data underscore the context-dependent association between the Pro12Ala polymorphism and cognitive decline, specifically race/ethnic background and sex.
|
29116943 |
2019 |
|
Mental deterioration
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our data underscore the context-dependent association between the Pro12Ala polymorphism and cognitive decline, specifically race/ethnic background and sex.
|
29116943 |
2019 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
The effect of</span> the PPARG rs1801282 G allele on ischemic stroke</span> risk was enhanced in the presence of the rs3856806 T allele (OR = 8.001 vs. 1.844).
|
31290457 |
2019 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our population and ethnic-based study demonstrates that the 162Val allele frequency was extremely low in the Chinese Uyghur Population different from Some European and African populations and the PPARγ 12 Pro/Ala resulting in an amino acid exchange in N-terminal sequence may be an independent protective factor for IS in the Chinese Uyghur Population.
|
30697628 |
2019 |
|
Sleep Apnea, Obstructive
|
|
0.010 |
GeneticVariation
|
BEFREE |
Subjects with the PPARG rs1801282 CG genotype had decreased risk of having OSA compared with subjects with the CC genotype after adjusting for confounding effects.
|
31044373 |
2019 |
|
Myocardial Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
PPARG2 Pro12Ala and TNF<i>α</i> -308G>A Polymorphisms Are Not Associated with Heart Failure Development in Patients with Ischemic Heart Disease after Coronary Artery Bypass Grafting.
|
31275366 |
2019 |
|
Heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study did not reveal any correlation between the <i>PPARG2</i> Pro12Ala and <i>TNFα</i> -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.
|
31275366 |
2019 |
|
Congestive heart failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our study did not reveal any correlation between the <i>PPARG2</i> Pro12Ala and <i>TNFα</i> -308G>A polymorphisms and development of HF in patients with ischemic heart disease after coronary bypass grafting.
|
31275366 |
2019 |
|
Angina, Unstable
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results of our study suggest the association between PPARG rs1801282 G allele and unstable angina in Polish population.
|
31252163 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
BEFREE |
Albeit small, our study may suggest that other pathways in AT or effects exerted in other tissues might contribute to the Pro12Ala-mediated protection against T2D.
|
30064293 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A Large Multiethnic Genome-Wide Association Study of Adult Body Mass Index Identifies Novel Loci.
|
30108127 |
2018 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
|
29273807 |
2018 |
|
Metabolic Syndrome X
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to establish associations between MetS-related abnormalities and the <i>PPAR-γ</i> rs1801282, <i>FTO</i> rs9939609, and <i>MC4R</i> rs17782313 polymorphisms.
|
29315078 |
2018 |
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future.
|
29464546 |
2018 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, the impact of total energy intake on obesity in Pro12Ala</span> carriers seemed to be stronger than that in the wild-type genotype carriers.
|
30122193 |
2018 |
|
Colorectal Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Several studies evaluated the association between peroxisome proliferators-activated receptor gamma (PPARγ) Pro12Ala (rs1801282), and His477His (rs3856806) polymorphisms and the risk of colorectal cancer (CRC).However, the results were not stable.
|
29970681 |
2018 |
|
Gestational Diabetes
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs1801282 polymorphism may not be associated with genetic susceptibility to GDM in whites.
|
29885389 |
2018 |
|
Malignant neoplasm of breast
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated associations between TNF-α <sup>-308</sup>G > A (rs1800629); PPARγ Pro<sup>12</sup>Ala (rs1801282); and IRS-1 Gly<sup>972</sup>Arg (rs1801278) polymorphisms and anthropometric variables, circulating levels of previously measured biomarkers, and tumor characteristics in 553 women enrolled in the Health, Eating, Activity, and Lifestyle Study, a multiethnic, prospective cohort study of women diagnosed with stage I-IIIA breast cancer between 1995 and 1999 (median follow-up 14.7 years).
|
29256014 |
2018 |
|
Breast Carcinoma
|
|
0.070 |
GeneticVariation
|
BEFREE |
We investigated associations between TNF-α <sup>-308</sup>G > A (rs1800629); PPARγ Pro<sup>12</sup>Ala (rs1801282); and IRS-1 Gly<sup>972</sup>Arg (rs1801278) polymorphisms and anthropometric variables, circulating levels of previously measured biomarkers, and tumor characteristics in 553 women enrolled in the Health, Eating, Activity, and Lifestyle Study, a multiethnic, prospective cohort study of women diagnosed with stage I-IIIA breast cancer between 1995 and 1999 (median follow-up 14.7 years).
|
29256014 |
2018 |
|
Pediatric Obesity
|
|
0.030 |
GeneticVariation
|
BEFREE |
LEPR rs1137101 and PPARG-2 rs1801282 had weak and medium negative effects on zBMI, respectively, and may slightly protect against childhood obesity.
|
29679223 |
2018 |